Changes in hepatic metabolic profile during the evolution of STZ-induced diabetic rats via an 1H NMR-based metabonomic investigation

@inproceedings{Chen2019ChangesIH,
  title={Changes in hepatic metabolic profile during the evolution of STZ-induced diabetic rats via an 1H NMR-based metabonomic investigation},
  author={Minjiang Chen and Hong Chun Zheng and Min Xu and Liangcai Zhao and Qianqian Zhang and Jingjing Song and Zhongwei Zhao and Siming Lu and Qiaoyou Weng and Xulu Wu and Weibin Yang and Xiaoxi Fan and Hongchang Gao and Jiansong Ji},
  booktitle={Bioscience reports},
  year={2019}
}
Background: The present study aimed to explore the changes in the hepatic metabolic profile during the evolution of diabetes mellitus (DM) and verify the key metabolic pathways. Methods: Liver samples were collected from diabetic rats induced by streptozotocin (STZ) and rats in the control group at 1, 5, and 9 weeks after STZ administration. Proton nuclear magnetic resonance spectroscopy (1H NMR)-based metabolomics was used to examine the metabolic changes during the evolution of DM, and… CONTINUE READING

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