Changes in haemostasis during normal pregnancy: does homocysteine play a role in maintaining homeostasis?

@article{Holmes2003ChangesIH,
  title={Changes in haemostasis during normal pregnancy: does homocysteine play a role in maintaining homeostasis?},
  author={V A Holmes},
  journal={The Proceedings of the Nutrition Society},
  year={2003},
  volume={62 2},
  pages={479-93}
}
  • V A Holmes
  • Published 2003 in The Proceedings of the Nutrition Society
Homocysteine, derived from the demethylation of the amino acid methionine, is either further catabolised by trans-sulfuration to cysteine or remethylated to methionine. Remethylation to methionine requires the cofactors, folate and vitamin B12. Folate is an effective homocysteine-lowering agent and, thus, homocysteine and folate status are inversely related. Hyperhomocysteinaemia is a strong independent risk factor for venous thromboembolism (VTE) and is associated with adverse pregnancy… CONTINUE READING