Changes in growth factor levels in human wound fluid.

  title={Changes in growth factor levels in human wound fluid.},
  author={Victoria M Dvonch and R J Murphey and Jo Matsuoka and Gary R. Grotendorst},
  volume={112 1},
BACKGROUND It has been suggested that platelet-derived growth factor (PDGF) plays a central role in wound healing. Analysis of human wound fluid revealed the presence of PDGF AA (30 kd) and monocyte/macrophage-derived growth factor (MDGF) (12 to 14 kd) in the immediate postoperative period. METHODS The amount of PDGF AA present was assayed by Western blot analysis. The chemotactic and mitogenic potential of purified wound fluid containing PDGF AA and MDGF was determined on a responsive cell… CONTINUE READING