Changes in glomerular kidney function among HIV-1-uninfected men and women receiving emtricitabine-tenofovir disoproxil fumarate preexposure prophylaxis: a randomized clinical trial.

@article{Mugwanya2015ChangesIG,
  title={Changes in glomerular kidney function among HIV-1-uninfected men and women receiving emtricitabine-tenofovir disoproxil fumarate preexposure prophylaxis: a randomized clinical trial.},
  author={Kenneth K Mugwanya and C. M. Wyatt and Connie L Celum and Deborah Donnell and Nelly R. Mugo and Jordan W. Tappero and James N Kiarie and Allan R. Ronald and Jared M Baeten},
  journal={JAMA internal medicine},
  year={2015},
  volume={175 2},
  pages={246-54}
}
IMPORTANCE Tenofovir disoproxil fumarate (TDF) use has been associated with declines in the estimated glomerular filtration rate (eGFR) when used as part of antiretroviral treatment by persons with human immunodeficiency virus (HIV) type 1, but limited data are available for risk when used as preexposure prophylaxis (PrEP) for HIV-1 prevention. OBJECTIVE To determine whether TDF-based PrEP causes eGFR decline in HIV-1-uninfected adults. DESIGN, SETTING, AND PARTICIPANTS A per-protocol… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 35 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 39 references

Emtricitabine/Tenofovir Disoproxil Fumarate Prescribing Information. http: //www.gilead.com/~/media/Files/pdfs/medicines /hiv/truvada/truvada_pi.PDF

Gilead Sciences
Accessed September • 2014

Association between tenofovir exposure and reduced kidney function in a cohort of HIV-positive patients: results from 10 years of follow-up.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America • 2013
View 1 Excerpt

Similar Papers

Loading similar papers…