Changes in gene expression profile induced by the anticancer agent Aplidine in Molt-4 leukemic cell lines.

@article{Marchini2002ChangesIG,
  title={Changes in gene expression profile induced by the anticancer agent Aplidine in Molt-4 leukemic cell lines.},
  author={Sergio Marchini and Giovanna Chiorino and Glynn T. Faircloth and Maurizio D'Incalci},
  journal={Journal of biological regulators and homeostatic agents},
  year={2002},
  volume={16 3},
  pages={241-8}
}
Microarray technique was employed to study differences in gene expression profile induced by Aplidine treatment in the Molt-4 human leukemic T cell line. Aplidine is a novel marine compound purified from caribbean tunicate (sea squirt) Aplidium Albicans. Despite promising anti-tumor activity, few data are available on its mechanism of action. Exponentially growing cells were treated with Aplidine concentrations close to its 5IC50 for 1 hour and RNA samples collected after 0.5, 1, 6 and 24 hours… CONTINUE READING

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