Changes in gene expression of phenylethanolamine N-methyltransferase in the transplanted human heart.

@article{Gonalvesov2004ChangesIG,
  title={Changes in gene expression of phenylethanolamine N-methyltransferase in the transplanted human heart.},
  author={Eva Gonçalvesov{\'a} and Lucia Micutkova and Boris Mravec and Lucia K{\vs}inantov{\'a} and Oľga Kri{\vz}anov{\'a} and Juraj Fabian and Richard Kvetňansk{\'y}},
  journal={Annals of the New York Academy of Sciences},
  year={2004},
  volume={1018},
  pages={430-6}
}
Heart transplantation (HTx) is an accepted treatment for precisely defined patients with chronic congestive heart failure; however, as a result of the procedure, the graft is completely denervated. Our study focused on the catecholamine biosynthetic pathway, that is, the production of epinephrine, which is known to have positive chronotropic and inotropic effects on the heart. mRNA levels of the phenylethanolamine N-methyltransferase (PNMT), the enzyme catalyzing epinephrine synthesis in… CONTINUE READING
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