Changes in free insulin-like growth factor-1 and leptin concentrations during acute metabolic decompensation in insulin withdrawn patients with type 1 diabetes.

@article{Attia1999ChangesIF,
  title={Changes in free insulin-like growth factor-1 and leptin concentrations during acute metabolic decompensation in insulin withdrawn patients with type 1 diabetes.},
  author={Najya A Attia and Sonia Caprio and Timothy W Jones and Rubina A. Heptulla and John Holcombe and David Silver and Robert S. Sherwin and William V Tamborlane},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1999},
  volume={84 7},
  pages={2324-8}
}
UNLABELLED To determine the effect of acute insulin withdrawal and its subsequent replacement on components of the insulin-like growth factor (IGF)-1 binding protein system and on circulating leptin levels in patients with type 1 diabetes. Seventeen patients (age 31 yr +/-10) with type 1 diabetes treated with continuous subcutaneous insulin infusion (HbA1c 7.6% +/-1.0) were studied. The protocol consisted of two phases: acute insulin withdrawal of up to 8 h followed by a further 2-h period of… CONTINUE READING

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