Changes in extracellular matrix and in transforming growth factor beta isoforms after coronary artery ligation in rats.

@article{Deten2001ChangesIE,
  title={Changes in extracellular matrix and in transforming growth factor beta isoforms after coronary artery ligation in rats.},
  author={Alexander Deten and Alexander Hoelzl and Monika Leicht and Wayne Barth and H. G. Zimmer},
  journal={Journal of molecular and cellular cardiology},
  year={2001},
  volume={33 6},
  pages={
          1191-207
        }
}
Extensive myocardial remodeling occurs after transmural myocardial infarction (MI). The infarcted myocardium is being replaced by scar tissue after gradual resorption of the necrotic tissue. The remodeling process involves both synthesis and degradation of collagens as major components of the extracellular matrix (ECM). In the present study we have analyzed the time-dependent changes of the processes related to this fibrosis in the infarct area and in the non-infarcted left ventricle (LV) six… CONTINUE READING
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