Changes in extracellular dopamine induced by morphine and cocaine: crucial control by D2 receptors.

@article{RougPont2002ChangesIE,
  title={Changes in extracellular dopamine induced by morphine and cocaine: crucial control by D2 receptors.},
  author={Françoise Roug{\'e}-Pont and Alessandro Usiello and Marianne Benoit-Marand and François G. Gonon and Pier Vincenzo Vincenzo Piazza and Emiliana Borrelli},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2002},
  volume={22 8},
  pages={
          3293-301
        }
}
An increase of extracellular dopamine (DA) concentration is a major neurobiological substrate of the addictive properties of drugs of abuse. In this article we investigated the contribution of the DA D2 receptor (D2R) in the control of this response. Extracellular DA levels were measured in the striatum of mice lacking D2R expression (D2R-/-) by in vivo microdialysis after administration of the psychostimulant cocaine and the opioid morphine. Interestingly, the increase in extracellular DA… CONTINUE READING

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