Changes in extracellular K+ evoked by GABA, THIP and baclofen in the guinea-pig hippocampal slice

Changes in [K+]0 evoked by the inhibitory amino acid transmitter, GABA (γ-aminobutyric acid) and its agonists were recorded with ion-selective microelectrodes in the CA1 stratum pyramidale of guinea-pig hippocampal slices. Bath applications of GABA (0.1–10 mM) produced dose-dependent increases in [K+]0 (EC50 = 4 mM, Rmax= 1.6 mM), with a peak and decline… (More)