Changes in expression of the DNA repair protein complex DNA-dependent protein kinase after ischemia and reperfusion.

@article{Shackelford1999ChangesIE,
  title={Changes in expression of the DNA repair protein complex DNA-dependent protein kinase after ischemia and reperfusion.},
  author={Deborah A. Shackelford and Tetsuya Tobaru and Shilei Zhang and Justin A. Zivin},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1999},
  volume={19 12},
  pages={
          4727-38
        }
}
Reperfusion of ischemic tissue causes an immediate increase in DNA damage, including base lesions and strand breaks. Damage is reversible in surviving regions indicating that repair mechanisms are operable. DNA strand breaks are repaired by nonhomologous end joining in mammalian cells. This process requires DNA-dependent protein kinase (DNA-PK), composed of heterodimeric Ku antigen and a 460,000 Da catalytic subunit (DNA-PKcs). In this study, a rabbit spinal cord model of reversible ischemia… CONTINUE READING

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