Changes in energy expenditure resulting from altered body weight.

@article{Leibel1995ChangesIE,
  title={Changes in energy expenditure resulting from altered body weight.},
  author={Rudolph L. Leibel and Michael Rosenbaum and Jules Hirsch},
  journal={The New England journal of medicine},
  year={1995},
  volume={332 10},
  pages={
          621-8
        }
}
BACKGROUND No current treatment for obesity reliably sustains weight loss, perhaps because compensatory metabolic processes resist the maintenance of the altered body weight. We examined the effects of experimental perturbations of body weight on energy expenditure to determine whether they lead to metabolic changes and whether obese subjects and those who have never been obese respond similarly. METHODS We repeatedly measured 24-hour total energy expenditure, resting and nonresting energy… 

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