Changes in endocrine circadian rhythms as markers of physiological and pathological brain aging.

@article{Magri1997ChangesIE,
  title={Changes in endocrine circadian rhythms as markers of physiological and pathological brain aging.},
  author={F Magri and Marco Locatelli and Gianni Balza and G. Molla and Giovanni Cuzzoni and Marisa Fioravanti and Sebastiano Bruno Solerte and Ettore Ferrari},
  journal={Chronobiology international},
  year={1997},
  volume={14 4},
  pages={385-96}
}
We studied the circadian rhythm of plasma melatonin, growth hormone (GH), prolactin (PRL), adrenocorticotropic hormone (ACTH), and cortisol in 52 mentally healthy old subjects, 35 old demented patients, and 22 clinically healthy young controls. When compared to young controls, the circadian profile of plasma melatonin of old subjects, both demented or not, was clearly flattened, particularly during the night. The selective impairment of nocturnal melatonin secretion was significantly related to… CONTINUE READING

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