Changes in endocannabinoid and palmitoylethanolamide levels in eye tissues of patients with diabetic retinopathy and age-related macular degeneration.

@article{Matias2006ChangesIE,
  title={Changes in endocannabinoid and palmitoylethanolamide levels in eye tissues of patients with diabetic retinopathy and age-related macular degeneration.},
  author={Isabel Matias and Jia wei Wang and Aniello Schiano Moriello and Amelia Nieves and David F. Woodward and Vincenzo Di Marzo},
  journal={Prostaglandins, leukotrienes, and essential fatty acids},
  year={2006},
  volume={75 6},
  pages={413-8}
}
Cannabinoid receptors and the endocannabinoids (anandamide (N-arachidonoylethanolamine--AEA) and 2-arachidonoylglycerol (2-AG)), as well as the AEA congener, palmitoylethanolamide (PEA), are involved in ocular physiology. We measured endocannabinoid and PEA levels by isotope-dilution liquid chromatography-mass spectrometric analysis in post-mortem eye tissues of patients with diabetic retinopathy (DR) or age-related macular degeneration (AMD). In eyes with DR, significantly enhanced levels of… CONTINUE READING