Changes in cytosolic free calcium ion concentrations in individual rat granulosa cells: effect of luteinizing hormone-releasing hormone.


Changes in the cytosolic free calcium ion concentrations ([Ca2+]i) induced by LHRH were studied in individual rat granulosa cells using fura-2 microspectrofluorimetry. The resting [Ca2+]i concentration was 96.7 +/- 2.9 nM (n = 115). The majority of the granulosa cells responded to LHRH at doses between 10(-7) and 10(-5) M; the latter dose was the highest… (More)


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