Changes in cortical and pallidal oscillatory activity during the execution of a sensory trick in patients with cervical dystonia

  title={Changes in cortical and pallidal oscillatory activity during the execution of a sensory trick in patients with cervical dystonia},
  author={Joyce K. H. Tang and Neil Mahant and Danny I. Cunic and Robert Chen and Elena Moro and Anthony E. Lang and Andres M. Lozano and William D. Hutchison and Jonathan O. Dostrovsky},
  journal={Experimental Neurology},
The sensory and motor representation of synchronized oscillations in the globus pallidus in patients with primary dystonia.
In 15 patients with primary dystonia who were treated with bilateral chronic pallidal stimulation, the sensorimotor modulation of the oscillatory local field potentials (LFPs) recorded from the pallidal electrodes were investigated and correlated with the surface electromyograms in the affected muscles.
Site-specific decrease in cortical reactivity during sensory trick in cervical dystonia patients.
It is found that SeT induced a significant decrease in the amplitude of TEP elicited from M1 stimulation at ~210-260ms in patients, which correlated with symptom duration, adding support to the idea that reduced cortical facilitation underlies the phenomenon.
Pallidal and Cortical Oscillations in Freely Moving Patients With Dystonia.
OBJECTIVES To evaluate the correlation between the pallidal local field potentials (LFPs) activity and the cortical oscillations (at rest and during several motor tasks) in two freely moving patients
Oscillatory activity in the globus pallidus internus: Comparison between Parkinson’s disease and dystonia
Brain oscillatory dysfunctions in dystonia.
Toward adaptive deep brain stimulation for dystonia.
The authors summarize the scientific research to date on pathological oscillations in dystonia and address potential biomarkers that might be used as a feedback signal for controlling aDBS in patients with Dystonia.
Human basal ganglia recordings from implanted deep brain stimulation electrodes and the microlesion effect
Depth recordings from the basal ganglia of patients suffering from Parkinson’s disease (PD) or dystonia have revealed local field potential (LFP) activity in specific frequency bands. Depth
Neurophysiological insights in dystonia and its response to deep brain stimulation treatment
Neurophysiology studies in dystonia and its treatment with Deep Brain Stimulation are reviewed, including Transcranial magnetic stimulation studies, studies of reflexes and sensory processing, and oscillatory activity recordings including local field potentials, micro-recordings, EEG and evoked potentials.
Deep brain stimulation suppresses pallidal low frequency activity in patients with phasic dystonic movements.
The findings suggest that high frequency stimulation may suppress pathologically enhanced low frequency activity in patients with phasic dystonia, which may directly relate to modulation of pathological basal ganglia activity, whereas improvement in tonic features may depend on long-term plastic changes within the motor network.


Sensory tricks in cervical dystonia: Perceptual dysbalance of parietal cortex modulates frontal motor programming
It is proposed that a perceptual dysbalance induced by a sensory trick maneuver leads to a relative displacement of the egocentric midvertical reference to the opposite side and a decrease in motor cortex activity.
Patterning of globus pallidus local field potentials differs between Parkinson's disease and dystonia.
It is concluded that untreated and treated Parkinson's disease and dystonia are characterized by different spatiotemporal patterns of activity in the human pallidum.
Descending control of muscles in patients with cervical dystonia
Conventional assessment and the results of frequency analysis correlated, suggesting that a low‐frequency drive to neck muscle may be a general feature of simple rotational and more complex cervical dystonia.
Long-term outcome of bilateral pallidal deep brain stimulation for primary cervical dystonia
Ten patients with severe cervical dystonia unresponsive to medical treatment underwent bilateral globus pallidus internus (GPi) deep brain stimulation (DBS) and were followed for 31.9 ± 20.9 months, finding it is an effective long-term therapy in patients with CD.
Involvement of the medial pallidum in focal myoclonic dystonia: A clinical and neurophysiological case study
The phasic pallidal activity correlated with and led the myoclonic muscle activity, and the myoclonus was suppressed by bilateral pallidal DBS, suggesting that the medial pallidum was involved in the generation of theMyoclonic activity.
Trick maneuvers in cervical dystonia: Investigation of movement‐ and touch‐related changes in polymyographic activity
Results might indicate different physiological mechanisms in clinically indistinguishable antagonistic gestures in cervical dystonia patients with idiopathic CD.
Methods for microelectrode-guided posteroventral pallidotomy.
Methods for localizing the posteroventral globus pallidus intermus are described, and the use of microelectrodes to record single-unit activity and to microstimulate in human pallidum and its surrounding structures are described.
A Practical Guide to Wavelet Analysis.
A practical step-by-step guide to wavelet analysis is given, with examples taken from time series of the El Nino–Southern Oscillation (ENSO). The guide includes a comparison to the windowed Fourier