Changes in collagen metabolism in diseased muscle. I. Biochemical studies.

  title={Changes in collagen metabolism in diseased muscle. I. Biochemical studies.},
  author={Raili Myllyl{\"a} and Vilho V. Myllyl{\"a} and Uolevi Tolonen and Kiri I. Kivirikko},
  journal={Archives of neurology},
  volume={39 12},
Possible changes in collagen biosynthesis were studied in 50 patients with neuromuscular disorders and 14 controls. Type III procollagen aminoterminal propeptide concentrations and galactosylhydroxylysyl glucosyltransferase (GGT) activities were assayed in serum, and prolyl 4-hydroxylase and GGT activities were assayed in muscle biopsy specimens. All four assays showed significantly elevated values in cases of polymyositis, adult forms of muscular dystrophy, and amyotrophic lateral sclerosis… CONTINUE READING
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