Changes in coagulation patterns, blood loss and blood use after cardiopulmonary bypass: aprotinin vs tranexamic acid vs epsilon aminocaproic acid.

@article{Menichetti1996ChangesIC,
  title={Changes in coagulation patterns, blood loss and blood use after cardiopulmonary bypass: aprotinin vs tranexamic acid vs epsilon aminocaproic acid.},
  author={Antonio Calvani Laura Menichetti and Luigi Tritapepe and Sebastiano Sciarretta and Giuseppe Speziale and Alessandro Cogliati and Claudio Di Giovanni and Maurizio Pacilli and Anna Criniti},
  journal={The Journal of cardiovascular surgery},
  year={1996},
  volume={37 4},
  pages={
          401-7
        }
}
Cardiopulmonary bypass (CPB) increases risk of postoperative bleeding and need for transfusion. The aim of this study was to evaluate the effects of aprotinin, epsilon aminocaproic acid and tranexamic acid on coagulation patterns and need for banked blood transfusion. Ninety-six consecutive patients who underwent coronary artery bypass surgery were randomly assigned to 4 groups (24 patients each). The following parameters were monitored before, during and after CPB: activated lotting time… CONTINUE READING

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