Changes in clot deformability--a possible explanation for the epidemiological association between plasma fibrinogen concentration and myocardial infarction.

@article{Scrutton1994ChangesIC,
  title={Changes in clot deformability--a possible explanation for the epidemiological association between plasma fibrinogen concentration and myocardial infarction.},
  author={Michael C. Scrutton and Simon B. Ross-Murphy and Gordon M Bennett and Y Stirling and Thomas W. Meade},
  journal={Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis},
  year={1994},
  volume={5 5},
  pages={719-23}
}
This study examined the rheological properties of fibrin gels formed by adding thrombin to plasma samples from 99 subjects with fibrinogen concentrations ranging from 1.45 to 4.14 g/l. A highly significant (r = 0.757; P < 0.001) inverse correlation was observed between plasma fibrinogen concentration and the extent of clot deformability as estimated from the final value of the storage modulus (G') of the fibrin gel when obtained by rheological analysis. A similarly significant correlation (r… CONTINUE READING

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