Changes in citric acid cycle flux and anaplerosis antedate the functional decline in isolated rat hearts utilizing acetoacetate.

@article{Russell1991ChangesIC,
  title={Changes in citric acid cycle flux and anaplerosis antedate the functional decline in isolated rat hearts utilizing acetoacetate.},
  author={Ryan R Russell and Heinrich Taegtmeyer},
  journal={The Journal of clinical investigation},
  year={1991},
  volume={87 2},
  pages={384-90}
}
To determine the temporal relationship between changes in contractile performance and flux through the citric acid cycle in hearts oxidizing acetoacetate, we perfused isolated working rat hearts with either glucose or acetoacetate (both 5 mM) and freeze-clamped the tissue at defined times. After 60 min of perfusion, hearts utilizing acetoacetate exhibited… CONTINUE READING