Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks

@article{Kruhlak2006ChangesIC,
  title={Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks},
  author={Michael J. Kruhlak and Arkady Celeste and Graham Dellaire and Oscar Fern{\'a}ndez-Capetillo and Waltraud G. M{\"u}ller and James G. McNally and D. P. Bazett-Jones and Andr{\'e} Nussenzweig},
  journal={The Journal of Cell Biology},
  year={2006},
  volume={172},
  pages={823 - 834}
}
The repair of DNA double-strand breaks (DSBs) is facilitated by the phosphorylation of H2AX, which organizes DNA damage signaling and chromatin remodeling complexes in the vicinity of the lesion. The disruption of DNA integrity induces an alteration of chromatin architecture that has been proposed to activate the DNA damage transducing kinase ataxia telangiectasia mutated. However, little is known about the physical properties of damaged chromatin. In this study, we use a photoactivatable… CONTINUE READING
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A phosphatase

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