Changes in cell-cycle protein expression during experimental mesangial proliferative glomerulonephritis.

@article{Shankland1996ChangesIC,
  title={Changes in cell-cycle protein expression during experimental mesangial proliferative glomerulonephritis.},
  author={S J Shankland and Christian P. M. Hugo and Stephen R. Coats and Masaomi Nangaku and Raimund H Pichler and Katherine L Gordon and Jeffrey W. Pippin and James M Roberts and William G. Couser and Richard J Johnson},
  journal={Kidney international},
  year={1996},
  volume={50 4},
  pages={1230-9}
}
A characteristic response to mesangial cell injury is proliferation, which is closely linked to mesangial matrix accumulation and the progression of glomerular disease. Cell proliferation in non-renal cells in vitro is regulated at the level of the cell-cycle by specific cyclins and their catalytic partners, cyclin dependent kinases (CDK). Cyclin kinase inhibitors (CKI) prevent proliferation by inhibiting cell-cycle progression. However, the expression of cell-cycle regulatory proteins in the… CONTINUE READING
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