Changes in carnitine palmitoyltransferase-I mRNA abundance produced by hyperthyroidism and hypothyroidism parallel changes in activity.

@article{Mynatt1994ChangesIC,
  title={Changes in carnitine palmitoyltransferase-I mRNA abundance produced by hyperthyroidism and hypothyroidism parallel changes in activity.},
  author={Randall L. Mynatt and Edwards A. Park and Fayanne E. Thorngate and Hriday K. Das and George A. Cook},
  journal={Biochemical and biophysical research communications},
  year={1994},
  volume={201 2},
  pages={932-7}
}
To study the regulation of carnitine palmitoyltransferase-I by thyroid hormone, a cDNA was obtained by PCR amplification of DNA obtained by reverse transcription of rat liver RNA. CPT-I mRNA abundance was measured in livers of hyperthyroid, euthyroid and hypothyroid rats. In hypothyroid rats, the CPT-I mRNA levels decreased 40-fold relative to that of the hyperthyroid animals. These changes paralleled alterations in enzyme activity. These data suggest that CPT-I is regulated at the… CONTINUE READING

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