Changes in calcium homeostasis in acromegaly treated by pituitary adenomectomy.

  title={Changes in calcium homeostasis in acromegaly treated by pituitary adenomectomy.},
  author={Shoshi Takamoto and Hiroyuki Tsuchiya and Toshio Onishi and Shigeto Morimoto and Shunji Imanaka and Syuichi Mori and Yoshiki Seino and Tohru Uozumi and Yuichi Kumahara},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={61 1},
Patients with acromegaly have alterations in mineral metabolism. To determine the effect of correction of excess GH secretion on calcium metabolism, we studied 12 acromegalic patients before and 3-4 weeks after pituitary adenomectomy. Treatment of acromegaly resulted in significant decreases in both serum calcium [from 9.3 +/- 0.2 to 8.7 +/- 0.1 mg/dl (mean +/- SEM); P less than 0.01] and urinary calcium excretion (from 200 +/- 24 to 88 +/- 12 mg/24 h; P less than 0.0002). Serum phosphate also… CONTINUE READING
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