Changes in brain gene expression shared by scrapie and Alzheimer disease.

  title={Changes in brain gene expression shared by scrapie and Alzheimer disease.},
  author={J R Duguid and C W Bohmont and Ningai Liu and Wallace W. Tourtellotte},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={86 18},
We have isolated two recombinant cDNAs whose corresponding RNAs have an increased abundance in scrapie-infected hamster brain. DNA sequence analysis has shown that these two recombinants represent the genes for sulfated glycoprotein 2 and transferrin. The abundance of sulfated glycoprotein 2 RNA is increased in hippocampus from patients with Alzheimer disease and Pick disease, whereas transferrin RNA is not strongly modulated in these conditions. Expression of two previously identified scrapie… CONTINUE READING

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