Changes in brain function occur years before the onset of cognitive impairment.

@article{BeasonHeld2013ChangesIB,
  title={Changes in brain function occur years before the onset of cognitive impairment.},
  author={Lori Beason-Held and Joshua Oon Soo Goh and Yang Soo An and Michael A. Kraut and Richard J. O'Brien and Luigi Ferrucci and Susan M. Resnick},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2013},
  volume={33 46},
  pages={18008-14}
}
To develop targeted intervention strategies for the treatment of Alzheimer's disease, we first need to identify early markers of brain changes that occur before the onset of cognitive impairment. Here, we examine changes in resting-state brain function in humans from the Baltimore Longitudinal Study of Aging. We compared longitudinal changes in regional cerebral blood flow (rCBF), assessed by (15)O-water PET, over a mean 7 year period between participants who eventually developed cognitive… CONTINUE READING
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