Changes in brain β-amyloid deposition and aquaporin 4 levels in response to altered agrin expression in mice.

@article{Rauch2011ChangesIB,
  title={Changes in brain β-amyloid deposition and aquaporin 4 levels in response to altered agrin expression in mice.},
  author={Steven M Rauch and Kathy H Y Huen and Miles Miller and Hira Chaudry and Melissa Lau and Joshua R Sanes and Conrad Earl Johanson and Edward G. Stopa and Robert W Burgess},
  journal={Journal of neuropathology and experimental neurology},
  year={2011},
  volume={70 12},
  pages={1124-37}
}
Conditions that compromise the blood-brain barrier (BBB) have been increasingly implicated in the pathogenesis of Alzheimer disease (AD). AGRIN is a heparan sulfate proteoglycan found abundantly in basement membranes of the cerebral vasculature, where it has been proposed to serve a functional role in the BBB. Furthermore, AGRIN is the major heparan sulfate proteoglycan associated with amyloid plaques in AD brains. To examine the relationship of AGRIN, the BBB, and AD-related pathologies, we… CONTINUE READING
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