Changes in bone mineralization, architecture and mechanical properties due to long-term (1 year) administration of pamidronate (APD) to adult dogs

@article{Grynpas1992ChangesIB,
  title={Changes in bone mineralization, architecture and mechanical properties due to long-term (1 year) administration of pamidronate (APD) to adult dogs},
  author={Dr M. D. Grynpas and A J Acito and M E Dimitriu and B. P. Mertz and J. M. Very},
  journal={Osteoporosis International},
  year={1992},
  volume={2},
  pages={74-81}
}
The goal of this study was to evaluate the effect of 1 year of APD administration on bone mineralization and bone mineral chemistry in the dog. Disodium pamidronate (APD) was given orally by gavage to mature beagle dogs at doses of 0, 2.5, 12.5 and 25.0 mg/kg per day (0.1% concentration for 12 months) as part of a long-term toxicity study. The os ilium and a vertebra were used to determine the mineralization profile and, subsequently, each density fraction was analysed chemically. Theribs were… CONTINUE READING

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