Changes in bone mineral density and bone-specific alkaline phosphatase in ovariectomized ewes.

@article{Turner1995ChangesIB,
  title={Changes in bone mineral density and bone-specific alkaline phosphatase in ovariectomized ewes.},
  author={Anthony Simon Turner and Mark Alvis and Wendy Myers and Mitchell L. Stevens and Mark Walden Lundy},
  journal={Bone},
  year={1995},
  volume={17 4 Suppl},
  pages={395S-402S}
}
An animal model of human osteoporosis which adequately meets many of the criteria needed to test new therapeutic agents is currently unavailable. The old ewe may serve this purpose, as changes in bone remodeling occur within 3 months, and a difference in bone mass has been indicated 6 months after ovariectomy. In the current study, we have measured longitudinal changes in bone mass and bone-specific alkaline phosphatase (BSAP) for six months in 7-9 year old ovariectomized (OVX) ewes. Thirty… CONTINUE READING

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