Changes in benzodiazepine receptors by acute stress: different effect of chronic diazepam or RO 15-1788 treatment.

@article{Medina1983ChangesIB,
  title={Changes in benzodiazepine receptors by acute stress: different effect of chronic diazepam or RO 15-1788 treatment.},
  author={Jorge H Medina and Maria Laura Novas and Eduardo de Robertis},
  journal={European journal of pharmacology},
  year={1983},
  volume={96 3-4},
  pages={
          181-5
        }
}
In rats submitted to acute stress by forced swimming there was an immediate sharp decline in the binding of [3H]flunitrazepam and of [3H]ethyl-beta-carboline-3-carboxylate in synaptosomal membranes of the cerebral cortex and hippocampus. This was followed by a rebound increase in benzodiazepine receptors after 60 min, specially in the hippocampal formation. These two changes were blocked by chronic treatment with diazepam for 14 days (4 mg/kg/day). On the other hand, long-term treatment with… CONTINUE READING

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