Changes in association of the Xenopus origin recognition complex with chromatin on licensing of replication origins.

@article{Rowles1999ChangesIA,
  title={Changes in association of the Xenopus origin recognition complex with chromatin on licensing of replication origins.},
  author={Alison Rowles and Shunsuke Tada and J. Julian Blow},
  journal={Journal of cell science},
  year={1999},
  volume={112 ( Pt 12)},
  pages={
          2011-8
        }
}
During late mitosis and early G1, a series of proteins are assembled onto replication origins that results in them becoming 'licensed' for replication in the subsequent S phase. In Xenopus this first involves the assembly onto chromatin of the Xenopus origin recognition complex XORC, and then XCdc6, and finally the RLF-M component of the replication licensing system. In this paper we examine changes in the way that XORC associates with chromatin in the Xenopus cell-free system as origins become… CONTINUE READING

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