Changes in apolipoprotein E expression in response to dietary and pharmacological modulation of cholesterol

@article{Petanceska2003ChangesIA,
  title={Changes in apolipoprotein E expression in response to dietary and pharmacological modulation of cholesterol},
  author={Suzana S. Petanceska and Steven C. Derosa and Ali Sharma and Nichole S. Diaz and Karen E Duff and Steven G. Tint and Lorenzo M. Refolo and Miguel A Pappolla},
  journal={Journal of Molecular Neuroscience},
  year={2003},
  volume={20},
  pages={395-406}
}
Apolipoprotein E (ApoE) influences the risk of late onset Alzheimer’s disease (AD) in an isoform-dependent manner, such that the presence of the apoE ε4 allele increases the risk of AD while the presence of the apoE ε2 allele appears to be protective. Although a number of ApoE functions are isoform dependent and may underlie the “risk factor” activity of AD, its ability to bind amyloid β peptides and influence their clearance and/or deposition has gained strong experimental support. Evidence… CONTINUE READING
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