Changes in apical dendritic structure correlate with sustained ERK1/2 phosphorylation in medial prefrontal cortex of a rat model of dopamine D1 receptor agonist sensitization.

@article{Papadeas2008ChangesIA,
  title={Changes in apical dendritic structure correlate with sustained ERK1/2 phosphorylation in medial prefrontal cortex of a rat model of dopamine D1 receptor agonist sensitization.},
  author={Sophia T Papadeas and Christopher Halloran and Thomas J. McCown and George R. Breese and Bonita L Blake},
  journal={The Journal of comparative neurology},
  year={2008},
  volume={511 2},
  pages={271-85}
}
Rats lesioned with 6-hydroxydopamine (6-OHDA) as neonates exhibit behavioral and neurochemical abnormalities in adulthood that mimic Lesch-Nyhan disease, schizophrenia, and other developmental disorders of frontostriatal circuit dysfunction. In these animals a latent sensitivity to D1 agonists is maximally exposed by repeated administration of dopamine… CONTINUE READING