Changes in angiogenesis and hypoxia-inducible factor-1α protein expression in relapsed/refractory indolent non-Hodgkin lymphomas.

Abstract

Angiogenesis is involved in the pathogenesis and progression of non-Hodgkin lymphomas (NHL), and hypoxia-inducible factor-1α (HIF-1α, also termed HIF1A) might contribute to this process. Currently, there is no direct evidence that the clinical progression of indolent NHL is associated with angiogenesis, and the expression of HIF-1α at recurrence is unknown. Matched lymph node biopsies at diagnosis and recurrence of relapsed/refractory indolent NHL patients were analysed by immunohistochemical and morphometric analysis. We observed an increased vascular network and HIF-1α protein expression in the second biopsy, providing direct evidence that angiogenesis is an essential process for disease progression.

DOI: 10.1111/bjh.12560

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Cite this paper

@article{Minoia2013ChangesIA, title={Changes in angiogenesis and hypoxia-inducible factor-1α protein expression in relapsed/refractory indolent non-Hodgkin lymphomas.}, author={Carla Minoia and Carmela Quero and Mariaconsilia Asselti and Ida Galise and Alessia L Marzano and Angela Iacobazzi and Antonio Rana and Francesca Merchionne and Simona Serrat{\`i} and Giacoma De Tullio and Giovanni Quintana and Michela Casiello and Eugenio Maiorano and Giovanni Simone and Francesco Alfredo Zito and Pasquale Iacopino and Attilio Guarini}, journal={British journal of haematology}, year={2013}, volume={163 5}, pages={640-5} }