Changes in adenosine 5'-monophosphate-activated protein kinase as a mechanism of visceral obesity in Cushing's syndrome.

@article{Kola2008ChangesIA,
  title={Changes in adenosine 5'-monophosphate-activated protein kinase as a mechanism of visceral obesity in Cushing's syndrome.},
  author={Blerina P Kola and Mirjam Christ-Crain and Francesca Lolli and Giorgio Arnaldi and Gilberta Giacchetti and Marco Boscaro and Ashley B. Grossman and M{\'a}rta Korbonits},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2008},
  volume={93 12},
  pages={
          4969-73
        }
}
OBJECTIVE Features of the metabolic syndrome such as central obesity with insulin resistance and dyslipidemia are typical signs of Cushing's syndrome and common side effects of prolonged glucocorticoid treatment. AMP-activated protein kinase (AMPK), a key regulatory enzyme of lipid and carbohydrate metabolism as well as appetite, is involved in the development of the deleterious metabolic effects of excess glucocorticoids, but no data are available in humans. In the current study, we… CONTINUE READING

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AMPK Activity in Cushing’s Syndrome

  • G Arnaldi, A Angeli, AB Atkinson, X Bertagna, F Cavagnini, GP Chrousos
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