Changes in Whole-Body Oxygen Consumption and Skeletal Muscle Mitochondria During Linezolid-Induced Lactic Acidosis.

@article{Protti2016ChangesIW,
  title={Changes in Whole-Body Oxygen Consumption and Skeletal Muscle Mitochondria During Linezolid-Induced Lactic Acidosis.},
  author={Alessandro Protti and Dario Ronchi and Gabriele Bassi and Francesco Fortunato and Andreina Bordoni and Tommaso Rizzuti and Roberto Fumagalli},
  journal={Critical care medicine},
  year={2016},
  volume={44 7},
  pages={e579-82}
}
OBJECTIVE To better clarify the pathogenesis of linezolid-induced lactic acidosis. DESIGN Case report. SETTING ICU. PATIENT A 64-year-old man who died with linezolid-induced lactic acidosis. INTERVENTIONS Skeletal muscle was sampled at autopsy to study mitochondrial function. MEASUREMENTS AND MAIN RESULTS Lactic acidosis developed during continuous infusion of linezolid while oxygen consumption and oxygen extraction were diminishing from 172 to 52 mL/min/m and from 0.27 to 0.10… CONTINUE READING
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