Changes in Visceral and Subcutaneous Fat in Youth With Type 2 Diabetes in the TODAY Study.

@article{Dhaliwal2019ChangesIV,
  title={Changes in Visceral and Subcutaneous Fat in Youth With Type 2 Diabetes in the TODAY Study.},
  author={R. Dhaliwal and John A. Shepherd and Laure El Ghormli and Kenneth C. Copeland and Mitchell E Geffner and Janine A. Higgins and Lynne L. Levitsky and Kristen J. Nadeau and Ruth S. Weinstock and Neil H. White},
  journal={Diabetes care},
  year={2019}
}
OBJECTIVE In TODAY, metformin plus rosiglitazone (M + R) maintained glycemic control better than metformin alone (M) or metformin plus lifestyle (M + L) in youth with type 2 diabetes (T2D). We hypothesized that changes in visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) would explain the differential treatment effects on glycemia. RESEARCH DESIGN AND METHODS In 626 youth ages 11-17 years with T2D duration <2 years, VAT and SAT were estimated by DXA at baseline and at 6 and… CONTINUE READING
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