Changes in Smad expression and subcellular localization in bleomycin-induced pulmonary fibrosis.

@article{Venkatesan2004ChangesIS,
  title={Changes in Smad expression and subcellular localization in bleomycin-induced pulmonary fibrosis.},
  author={Natarajan Venkatesan and Laura Pini and Mara S. Ludwig},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2004},
  volume={287 6},
  pages={L1342-7}
}
Administration of bleomycin (BM) produces inflammation and fibrosis of the lung in humans and experimental animals. The molecular defects by which BM induces these pathological effects have not been studied in detail. We studied the expression of Smad family proteins, key molecules involved in mediating transforming growth factor (TGF)-beta signaling from the cell membrane to the nucleus, during the early and late phases of BM-induced fibrogenesis. Pulmonary fibrosis was induced in male Sprague… CONTINUE READING