Changes in Proteasome Structure and Function Caused by HAMLET in Tumor Cells

@article{Gustafsson2009ChangesIP,
  title={Changes in Proteasome Structure and Function Caused by HAMLET in Tumor Cells},
  author={Lotta Gustafsson and Sonja Aits and Patrik {\"O}nnerfjord and Maria Trulsson and Petter Storm and Catharina Svanborg},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={522 - 523}
}
BACKGROUND Proteasomes control the level of endogenous unfolded proteins by degrading them in the proteolytic core. Insufficient degradation due to altered protein structure or proteasome inhibition may trigger cell death. This study examined the proteasome response to HAMLET, a partially unfolded protein-lipid complex, which is internalized by tumor cells and triggers cell death. METHODOLOGY/PRINCIPAL FINDINGS HAMLET bound directly to isolated 20S proteasomes in vitro and in tumor cells… CONTINUE READING

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HAMLET - In vivo effects and mechanisms of tumor-cell death [Doctoral Thesis

  • L Gustafsson
  • 2005
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