Changes in Plasma Mass-Spectral Profile in Course of Treatment of Non-small Cell Lung Cancer Patients with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors
@article{Lazzari2012ChangesIP, title={Changes in Plasma Mass-Spectral Profile in Course of Treatment of Non-small Cell Lung Cancer Patients with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors}, author={Chiara Lazzari and Anna Spreafico and Angela Bachi and Heinrich Roder and Irene C Floriani and Daniela Garavaglia and Angela Cattaneo and Julia Grigorieva and Maria Grazia Vigan{\'o} and Cristina Sorlini and Domenico Ghio and Maxim Tsypin and Alessandra Bulotta and Luca Bergamaschi and Vanesa Gregorc}, journal={Journal of Thoracic Oncology}, year={2012}, volume={7}, pages={40-48} }
Introduction: Our previous study showed that pretreatment serum or plasma Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry may predict clinical outcome of non-small cell lung cancer (NSCLC) patients treated with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). In this study, plasma proteomic profiles of NSCLC patients were evaluated in the course of EGFR TKIs therapy. Materials and Methods: Plasma samples were collected at baseline, in the…
38 Citations
Serum peptide expression and treatment responses in patients with advanced non-small-cell lung cancer.
- Biology, MedicineOncology letters
- 2018
It is confirmed that MALDI-TOF MS analysis can be used to predict responses to EGFR-TKI treatment of the Asian population where the EGFR mutation status differs from the European population.
Serum proteomic study on EGFR-TKIs target treatment for patients with NSCLC
- Medicine, BiologyOncoTargets and therapy
- 2013
It is shown that a proteomic classifier can predict the outcome of patients treated with EGFR-TKIs and may aid in patient selection in the absence of available tumor tissue.
SAA1 is over-expressed in plasma of non small cell lung cancer patients with poor outcome after treatment with epidermal growth factor receptor tyrosine-kinase inhibitors.
- Biology, MedicineJournal of proteomics
- 2012
Mass spectrometry-based serum and plasma peptidome profiling for prediction of treatment outcome in patients with solid malignancies.
- Biology, MedicineThe oncologist
- 2014
Pretreatment MS-based serum and plasma peptidomics have shown promising results for prediction of treatment outcome in patients with solid tumors, but additional prospective studies are warranted.
Predictive value of a serum-based proteomic test in non-small-cell lung cancer patients treated with epidermal growth factor receptor tyrosine kinase inhibitors: a meta-analysis
- Medicine, BiologyCurrent medical research and opinion
- 2014
A meta-analysis demonstrated that this serum-based proteomic test has a predictive value for NSCLC patients treated with EGFR-TKIs and its ‘good’ status predicted a better clinical outcome.
Mass spectrometry-based serum peptidome profiling accurately and reliably predicts outcomes of pemetrexed plus platinum chemotherapy in patients with advanced lung adenocarcinoma
- Medicine, BiologyPloS one
- 2017
The authors' predictive peptide model could predict pemetrexed plus platinum treatment outcomes in patients with advanced lung adenocarcinoma and might thus facilitate appropriate patient selection and further studies are needed to confirm these findings.
VeriStrat® has prognostic value in advanced stage NSCLC patients treated with erlotinib and sorafenib
- Medicine, BiologyBritish Journal of Cancer
- 2012
VeriStrat has shown its potential for stratification of unselected, advanced stage NSCLC patients treated in first line with a combination of erlotinib and sorafenib.
Predictive value of a proteomic signature in patients with non-small-cell lung cancer treated with second-line erlotinib or chemotherapy (PROSE): a biomarker-stratified, randomised phase 3 trial.
- MedicineThe Lancet. Oncology
- 2014
Epidermal growth factor receptor tyrosine kinase inhibitors in the treatment of NSCLC.
- Biology, MedicineLung cancer
- 2013
The Evolving Role of Maintenance Therapy Using Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors (EGFR TKIs) in the Management of Advanced Non-Small-Cell Lung Cancer
- BiologyClinical Medicine Insights. Oncology
- 2012
The current understanding of erlotinib's mechanism of action, with the discovery that EGFR mutation confers higher response rate, has propelled this agent into the first line setting.
References
SHOWING 1-10 OF 62 REFERENCES
Mass spectrometry to classify non-small-cell lung cancer patients for clinical outcome after treatment with epidermal growth factor receptor tyrosine kinase inhibitors: a multicohort cross-institutional study.
- MedicineJournal of the National Cancer Institute
- 2007
This predictive algorithm based on matrix-assisted laser desorption ionization (MALDI) mass spectrometry (MS) analysis of pretreatment serum could classify NSCLC patients for good or poor outcomes after treatment with EGFR TKIs.
Detection of Tumor Epidermal Growth Factor Receptor Pathway Dependence by Serum Mass Spectrometry in Cancer Patients
- Medicine, BiologyCancer Epidemiology, Biomarkers & Prevention
- 2010
Serum proteomic profiling can detect clinically significant tumor dependence on the EGFR pathway in non–small cell lung cancer, HNSCC, and CRC patients treated with either EGFR-TKIs or cetuximab and provides a clinically practical way to identify patients with diverse cancer types most likely to benefit from EGFR inhibitors.
Genetic and Proteomic Features Associated with Survival after Treatment with Erlotinib in First-Line Therapy of Non-small Cell Lung Cancer in Eastern Cooperative Oncology Group 3503
- Biology, MedicineJournal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
- 2010
The previously defined matrix-assisted laser desorption ionization predictor remains a potent and highly clinically significant predictor of survival after first-line treatment with erlotinib in patients with wild-type EGFR and independent of mutations in KRAS.
Comparison of epidermal growth factor receptor mutations between primary and corresponding metastatic tumors in tyrosine kinase inhibitor-naive non-small-cell lung cancer.
- Medicine, BiologyAnnals of oncology : official journal of the European Society for Medical Oncology
- 2009
Analysis of EGFR mutations in the primary lung tumor would be inadequate for planning the use of TKI for advanced NSCLC, as it does not always reflect the same situation in metastases.
Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced non-small-cell lung cancer.
- Biology, MedicineJournal of clinical oncology : official journal of the American Society of Clinical Oncology
- 2006
EGFR gene copy number was a predictor of clinical benefit from gefitinib in ISEL, and the limited amount of data collected for KRAS and BRAF mutations prevented any meaningful evaluation of clinical outcomes in relation to these mutations.
Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial.
- MedicineJAMA
- 2003
Gefitinib, a well-tolerated oral EGFR-tyrosine kinase inhibitor, improved disease-related symptoms and induced radiographic tumor regressions in patients with NSCLC persisting after chemotherapy.
Comparison Between Epidermal Growth Factor Receptor (EGFR) Gene Expression in Primary Non-small Cell Lung Cancer (NSCLC) and in Fine-Needle Aspirates from Distant Metastatic Sites
- MedicineJournal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
- 2008
It is found that EGFR gene copy number is discordant between primary NSCLC and the corresponding distant metastatic sites in a significant proportion of cases.
TGF-β IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer
- BiologyProceedings of the National Academy of Sciences
- 2010
It is argued that both tumor cell-autonomous mechanisms and/or activation of the tumor microenvironment could contribute to primary and acquired erlotinib resistance, and as such, treatments based on EGFR inhibition may not be sufficient for the effective treatment of lung-cancer patients harboring mutant EGFR.
EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
- Biology, MedicineScience
- 2004
Results suggest that EGFR mutations may predict sensitivity to gefitinib, and treatment with the EGFR kinase inhibitor gefitsinib causes tumor regression in some patients with NSCLC, more frequently in Japan.
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib.
- Biology, MedicineThe New England journal of medicine
- 2004
A subgroup of patients with non-small-cell lung cancer have specific mutations in the EGFR gene which correlate with clinical responsiveness to the tyrosine kinase inhibitor gefitinib, and these mutations lead to increased growth factor signaling and confer susceptibility to the inhibitor.