Changes in Parthenogenetic Imprinting Patterns during Reprogramming by Cell Fusion

@inproceedings{Jang2016ChangesIP,
  title={Changes in Parthenogenetic Imprinting Patterns during Reprogramming by Cell Fusion},
  author={Hyun Sik Jang and Yean Ju Hong and Hyun Woo Choi and Hyuk Song and Sung June Byun and Sang Jun Uhm and Han Geuk Seo and Jeong Tae Do},
  booktitle={PloS one},
  year={2016}
}
Differentiated somatic cells can be reprogrammed into the pluripotent state by cell-cell fusion. In the pluripotent state, reprogrammed cells may then self-renew and differentiate into all three germ layers. Fusion-induced reprogramming also epigenetically modifies the somatic cell genome through DNA demethylation, X chromosome reactivation, and histone modification. In this study, we investigated whether fusion with embryonic stem cells (ESCs) also reprograms genomic imprinting patterns in… CONTINUE READING
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