Changes in Natural Killer Cells, the CD57CD8 Subset, and Related Cytokines in Healthy Aging

@article{Mcnerlan1998ChangesIN,
  title={Changes in Natural Killer Cells, the CD57CD8 Subset, and Related Cytokines in Healthy Aging},
  author={Susan E. Mcnerlan and Irene Maeve Rea and Heather D Alexander and T C M Curly Morris},
  journal={Journal of Clinical Immunology},
  year={1998},
  volume={18},
  pages={31-38}
}
Aging has been shown to be accompanied by various changes in the lymphocyte subset distribution in the elderly. We have investigated more fully, and in a large number of subjects, age-related changes within several subpopulations bearing natural killer (NK) cell-associated surface antigens and changes in several cytokines involved in NK cell expansion. A total of 229 healthy subjects from all decades of life from 20 to 98 years of age was included in this cross-sectional study. A significant… CONTINUE READING

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Role of interleukin 15 in the development of the CD56+ NK cells from CD34+ hematopoietic progenitor cells

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