• Corpus ID: 43194262

Changes in Michaelis and spectral constants for aniline in hepatic microsomes from phenobarbital-treated rats.

@article{Guarino1969ChangesIM,
  title={Changes in Michaelis and spectral constants for aniline in hepatic microsomes from phenobarbital-treated rats.},
  author={Anthony M. Guarino and Theodore E. Gram and Philippe Gigon and Frank E. Greene and James R. Gillette},
  journal={Molecular pharmacology},
  year={1969},
  volume={5 2},
  pages={
          131-6
        }
}
Recent work has suggested that the rate of hepatic microsomal drug metabolism may be correlated with either the cytochrome P-450 content or the magnitude of the spectral change caused by the addition of substrates to microsomal suspensions. Accordingly, the relationships between these factors were investigated in 0.9% NaCl- and phenobarbital-treated intact, sham-operated, and partially hepatectomized rats. In intact animals phenobarbital produced a 3-4-fold increase in both microsomal aniline… 
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