Changes in Intermediary Metabolism in Severe Surgical Illness

  title={Changes in Intermediary Metabolism in Severe Surgical Illness},
  author={Robert R. Wolfe and Wenjun Znou Martini},
  journal={World Journal of Surgery},
Under normal circumstances there is a reciprocal relation between the availability of free fatty acids (FFAs) and glucose in plasma. In the fasted state, FFAs predominate in both availability and the relative contribution to energy production, whereas the same is true for glucose in the fed state. The extent of glucose oxidation is directly determined by its availability, whereas FFAs are normally available well in excess of their rate of oxidation. The rate of FFA oxidation is determined by… CONTINUE READING


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