Changes in IGF-I and -II expression and secretion during the proliferation and differentiation of normal rat osteoblasts.

IGF-I and -II have potent effects on proliferation and differentiation of osteoblasts in vitro. These cells secrete both IGFs and expression of these peptides is regulated by several of the hormones and growth factors that promote bone resorption and/or formation. However, the physiological role(s) of IGFs in the remodelling process of adult bone is still… CONTINUE READING