Changes in Human Immunodeficiency Virus Type 1 Envelope Glycoproteins Responsible for the Pathogenicity of a Multiply Passaged Simian-Human Immunodeficiency Virus (SHIV-HXBc2)

@article{Cayabyab1999ChangesIH,
  title={Changes in Human Immunodeficiency Virus Type 1 Envelope Glycoproteins Responsible for the Pathogenicity of a Multiply Passaged Simian-Human Immunodeficiency Virus (SHIV-HXBc2)},
  author={M. Cayabyab and G. Karlsson and B. Etemad-Moghadam and W. Hofmann and T. Steenbeke and M. Halloran and J. Fanton and M. Axthelm and N. Letvin and J. Sodroski},
  journal={Journal of Virology},
  year={1999},
  volume={73},
  pages={976 - 984}
}
  • M. Cayabyab, G. Karlsson, +7 authors J. Sodroski
  • Published 1999
  • Biology, Medicine
  • Journal of Virology
  • ABSTRACT In vivo passage of a poorly replicating, nonpathogenic simian-human immunodeficiency virus (SHIV-HXBc2) generated an efficiently replicating virus, KU-1, that caused rapid CD4+T-lymphocyte depletion and AIDS-like illness in monkeys (S. V. Joag, Z. Li, L. Foresman, E. B. Stephens, L.-J. Zhao, I. Adany, D. M. Pinson, H. M. McClure, and O. Narayan, J. Virol. 70:3189–3197, 1996). The env gene of the KU-1 virus was used to create a molecularly cloned virus, SHIV-HXBc2P 3.2, that differed… CONTINUE READING
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