Changes in Hsp90 expression determine the effects of cyclosporine A on the NO pathway in rat myocardium.

@article{Rezzani2003ChangesIH,
  title={Changes in Hsp90 expression determine the effects of cyclosporine A on the NO pathway in rat myocardium.},
  author={Rita Rezzani and Luigi Rodella and Chantal Dessy and G{\'e}raldine Daneau and Rossella Bianchi and Olivier F{\'e}ron},
  journal={FEBS letters},
  year={2003},
  volume={552 2-3},
  pages={125-9}
}
Cyclosporine A (CsA) is associated with the development of cardiovascular toxicity in transplant patients but can exert myocardial protection against ischemia/reperfusion damages. We examined in a rat model of chronic CsA administration whether subtle variations in the NO pathway could account for these opposite effects. CsA treatment rapidly led to an increase in myocardial Hsp90 expression promoting the recruitment of Akt and calcineurin, thereby promoting eNOS activation through Ser1177… CONTINUE READING
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