Changes in Hepato-Renal Tissues Biomarkers of Alloxan-Induced Diabetic Wistar Rats Co-Administered Monosodium Glutamate and Ascorbic Acid

  title={Changes in Hepato-Renal Tissues Biomarkers of Alloxan-Induced Diabetic Wistar Rats Co-Administered Monosodium Glutamate and Ascorbic Acid},
  author={Paul Chidoka Chikezie and Blessing Chinonso Ezeocha and Promise Nwankpa},
  journal={Biochemical Pharmacology},
The present study investigated the capacity of combined administration of monosodium glutamate (MSG) and ascorbic acid to reverse altered hepatorenal functions in Type 1 diabetes mellitus (DM) Wistar rats. Single intra-peritoneal (i.p.) injection of 90 mg/kg body weight (b.w.) of alloxan monohydrate in phosphate buffered saline (pH=7.4) was used to induce DM in the rats. Standard spectrophotometric methods were used to measure hepatorenal biomarkers; namely, serum alanine transaminase (ALT… Expand

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