Changes in GSH-antioxidant system induced by daunorubicin in human normal and diabetic fibroblasts.


We investigated the effect of daunorubicin on glutathione content and activity of GSH-related enzymes in cultured normal and diabetic human fibroblasts. Cells were incubated with 4 microM daunorubicin (DNR) for 2 h followed by culture in drug-free medium for up to 72 h. Treatment of diabetic cells with the drug caused a time-dependent depletion of… (More)


7 Figures and Tables