Changes in DNA synthesis rate in the Schwann cell lineage in vivo are correlated with the precursor--Schwann cell transition and myelination.

@article{Stewart1993ChangesID,
  title={Changes in DNA synthesis rate in the Schwann cell lineage in vivo are correlated with the precursor--Schwann cell transition and myelination.},
  author={Helen J S Stewart and Louise Morgan and Kristj{\'a}n R. Jessen and Rhona Mirsky},
  journal={The European journal of neuroscience},
  year={1993},
  volume={5 9},
  pages={1136-44}
}
During the development of the rat sciatic nerve extensive proliferation of glial cells occurs, and there is a very substantial rearrangement of the cytoarchitecture as axons and Schwann cells assume relationships which lead to the formation of the myelinated and unmyelinated axons characteristic of adult nerve. The maturation of Schwann cells from Schwann cell precursors and the matching of Schwann cell numbers to axons is an important part of this process. We have therefore studied the… CONTINUE READING

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